Oxandrolone Wikipedia

Oxandrolone Wikipedia

# Oxandrolone: An Overview

## Introduction
Oxandrolone is a synthetic steroid that has found medical applications but also faces misuse outside of prescribed uses. Understanding its properties and proper use is essential.

## Medical Uses
Oxandrolone is used for conditions like chronic obstructive pulmonary disease (COPD) and hypothyroidism. Studies show it can improve lung function and metabolic health in these cases.

## Non-Medical Uses
Despite its medical benefits, oxandrolone is misused in bodybuilding and anti-aging practices. Abuse risks include severe side effects, highlighting the need for regulated use.

## Contraindications
Avoid in infections, unresolved heart conditions, or pregnancy due to potential harm to the fetus and other health complications.

## Side Effects
Common effects include steroid-related issues like facial rounding and muscle atrophy. Serious ones involve organ damage, requiring immediate medical attention.

## Interactions
Interact with other drugs; additive effects may occur, increasing side effects risks. Consult healthcare providers before combining medications.

## Pharmacology & Pharmacodynamics
A synthetic dexamethasone derivative, oxandrolone works on cells via specific enzymes, affecting protein synthesis and immune response.

## Steroid Configuration
It is a racemic mixture with both enantiomers present, impacting efficacy and safety.

## Pharmacokinetics
Rapidly absorbed, metabolized quickly, with a short half-life, making it less suitable for long-term use without medical supervision.

## Chemistry
A dexamethasone analog with substitutions altering activity; structurally similar to other steroids but functionally distinct.

## History
Developed by Hoffmann-La Roche in the 1950s for specific conditions, its introduction marked a step in steroid therapy evolution.

## Society & Culture
Misuse is prevalent in gym cultures, prompting regulatory measures against non-prescribed use, including sports doping and controlled substance laws.

## Generic Names
Oxandrolone (INN), also known as 1-dehydro-4-formidin-1-one acetate; brand names include Oxandrolona and others.

## Availability
Available in tablet form for medical uses; misuse often involves other forms acquired illegally.

## Legal Status
A controlled substance, subject to strict regulations on possession and distribution without valid prescriptions.

## References
1. World Health Organization (WHO) 2023.
2. National Institute for Health and Care Excellence (NICE) guidelines, 2022.
3. ClinicalTrials.gov, accessed March 2024.

## External Links
– National Institute for Health and Care Excellence Guidelines(https://nice.org.uk)
– U.S. Food and Drug Administration (FDA)(https://www.fda.gov)

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This article provides a comprehensive overview of oxandrolone, balancing its medical uses with the importance of responsible use due to significant risks.

References:

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